Sex-specific Behavioral Features of Rodent Models of Autism Spectrum Disorder
نویسندگان
چکیده
منابع مشابه
Evidence for sex-specific risk alleles in autism spectrum disorder.
We investigated the genetic aspects of the large sex bias in the prevalence of autism spectrum disorder by monitoring changes in linkage when the family set for an affected sibling pair genome scan is subdivided on the basis of the sex of affected children. This produces a significant excess in the total number of linkage peaks (P=1.3 x 10(-8)) and identifies a major male-specific linkage peak ...
متن کاملUnderstanding sex bias in autism spectrum disorder.
Autism spectrum disorders (ASDs) have long been noted to affect many more males than females, and accordingly, sex-specific factors have been hypothesized to increase males’ risk for, or protect females from, ASDs. However, no such factor has been definitively implicated in ASD etiology that can account for its male-biased prevalence, nor is it known whether the major drivers of sex-differentia...
متن کاملAnimal Models of Autism Spectrum Disorder
Animal models are developed to test hypotheses about causes of disease, and potential treatments. With genetic, molecular, imaging and electrophysiological studies being supported by animal models, autism research has been flourishing in recent years. On different aspects of autism research, a significant number of reviews have been published. Several of them treated animal models to help curre...
متن کاملThe utility of rodent models of autism spectrum disorders.
PURPOSE OF REVIEW This review discusses the ways that rodent models of autism spectrum disorders (ASDs) have been used to gain critical information about convergent molecular pathways, the mechanisms underlying altered microcircuit structure and function, and as a screen for potential cutting edge-treatments for ASDs. RECENT FINDINGS There is convergent evidence that impaired developmental pr...
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ژورنال
عنوان ژورنال: Experimental Neurobiology
سال: 2018
ISSN: 1226-2560,2093-8144
DOI: 10.5607/en.2018.27.5.321